Diana Mitrea

Associate Director, Scientific Comms & Condensate Biophysics

Diana Mitrea

“Learn from yesterday, live for today, hope for tomorrow. The important thing is not to stop questioning.”

—Albert Einstein

PhD, Biochemistry and Molecular Biology, SUNY Upstate Medical University
BS, Biochemical Engineering, Babeş-Bolyai University
Current Affiliation
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Diana, a Romanian native, joined Dewpoint Therapeutics in the summer of 2019. She has a BS degree in Biochemical Engineering from Babeş-Bolyai University in Cluj-Napoca, Romania, and a PhD degree in Biochemistry and Molecular Biology from SUNY Upstate Medical University, in Syracuse, NY.

Diana’s fascination with the biology and structure-function relationship of biomolecular condensates started during her postdoctoral training in Dr. Richard Kriwacki’s lab. As a postdoctoral fellow and later a staff scientist at St. Jude Children’s Research Hospital, she discovered that the multifunctional, non-ribosomal protein nucleophosmin (NPM1) plays a central role in the formation of liquid-like, complex macromolecular networks. These networks represent the structural basis for the assembly of the granular component of the nucleolus, and likely contribute to regulation of ribosome biogenesis and stress sensing. In amyotrophic lateral sclerosis, or ALS, a debilitating neurodegenerative disease, these molecular networks in the nucleolus are disrupted, causing neuronal cell death. In addition to original research articles, Diana also contributed two review articles to the field of biomolecular condensates, which discuss the structure and function of biomolecular condensates, and the methodological arsenal used to study them.

Diana Mitrea
Diana Mitrea
Diana Mitrea