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Jonathan O’Connell

Head of Discovery Platform
Jonathan O’Connell

Jonathan is responsible for Dewpoint’s Discovery Platform, which encompasses High Throughput Screening (HTS) and Compound Management, In Vitro Pharmacology (IVP), Laboratory Operations, as well as Lab Informatics. Jonathan’s teams are at both our Boston and Dresden locations. Jonathan brings more than 27 years of experience in drug discovery.

Prior to joining Dewpoint, he was Vice President, Head of Early Discovery and Technology at Valo Health. It was his team at FORMA Therapeutics that was acquired by Valo in 2020. He joined FORMA in 2013 and was tasked with establishing a world-class HTS and Hit-to-Lead support operation. His role evolved to join the leadership and head up FORMA’s Early Discovery Team over two sites with responsibility for compound management, HTS, IVP, ADME, Automated & Early Discovery Chemistry. Jonathan also served as acting head of Biology at Valo Health, covering Oncology, Neurodegenerative and Cardiovascular, as well as ad interim Head of Discovery at FORMA therapeutics where he led the Hematology/Oncology biology and medicinal chemistry teams.

Prior to joining FORMA, Jonathan had accumulated 18 years of experience at Glaxo Smith Klein (GSK) and Bristol Myers Squibb (BMS). It was in his first industry role at GSK as an assay designer for high-throughput screening that he found he could merge his passion for biochemistry and enzymology with his interest in automation and technology. As Director at BMS, he drove innovative technology leveraging strategies, leading multiple teams, including a centralized HTS facility, a lead optimization group for neuroscience and virology and a centralized in vitro ADME team supporting programs across six therapeutic areas.

Jonathan received a Bachelor of Science degree in Biochemistry at the University of Manchester in the United Kingdom and subsequently went on to obtain a Ph.D. in Biochemistry at the University of Glasgow. For his Ph.D., he worked under the leadership of Professor Miles Houslay, studying enzymology and cellular localization of type IV phosphodiesterases. Jonathan has authored over 30 publications and presented at countless conferences throughout his career. As a global leader in the Early Discovery field, he is recognized as a Fellow Member of the Society for Laboratory Automation and Screening (SLAS) and has served as a member of the SLAS Board of Directors between 2021-2023.

Outside of work Jonathan loves to build things and has made pool houses, sheds, as well as a few chicken coops to house the family flock led by Hennifer Lopez. He also loves to cook with his family, be it grilling, smoking, knocking up a good Indian curry or even baking, it doesn’t matter, so long as everyone enjoys the food!

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