Aravind’s research at the Broad Institute focused on technologies for generating large-scale perturbational datasets and their computational analysis.
Over the past decade, Aravind’s team has generated several large perturbation datasets by treating cultured human cells with small-molecule and biological agents.
These data, coupled with powerful pattern recognition algorithms, are made available in a popular public resource called the Connectivity Map and are routinely used by drug hunters to understand mechanisms of action of small-molecules, functionally annotate disease genes, and inform clinical studies.
Design: SALIENCE Communication / Publiepress
Scientific animation: Visual Science