Scientist / Sr. Scientist – Medicinal Chemistry (m/f/d)


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Dewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.

We are searching for an enthusiastic and highly motivated Scientist / Senior Scientist, Medicinal Chemistry, as an elemental part of our internal chemistry & drug discovery group. You will provide essential input for the design and synthesis of small molecules.

In this position you’ll be part of an energizing and supportive startup culture engaged in continuous learning, and part of an exceptional international team. This role will be based at our site in Frankfurt, Germany. Dewpoint offers great benefits, competitive salary, and amazing perks.

In this role you will…

  • Be part of a cross-functional project team and responsible for the successful delivery of lead molecules and new clinical candidates
  • Analyze complex data sets to generate structure activity relationships and use that understanding for molecule optimization

  • Design and synthesize biologically active, condensate modulating small molecule drugs and also explore new chemical modalities

  • Efficiently manage a medicinal chemistry laboratory with research associates

  • Help to build out the lab infrastructure and operations at our new chemistry site in Frankfurt

  • Promote and maintain the highest levels of excellence in medicinal chemistry, with a personal commitment to extend and develop knowledge and expertise

  • Discuss, present and publish research results internally and externally at scientific conferences

  • Become a valuable contributor to other initiatives as they arise in our fast paced, startup environment 

To do that you will need…

  • A Ph.D. in synthetic organic chemistry, medicinal chemistry, or a related discipline

  • 2+ years of experience in applying synthetic organic chemistry / medicinal chemistry in an industry setting

  • Comprehensive state-of-the-art knowledge in modern synthetic methodologies and medicinal chemistry

  • Strong knowledge of techniques related to purification and characterization of organic compounds

  • An understanding of the drug discovery process including related scientific disciplines mandatory for driving successfully medicinal chemistry projects (biology, ADME, drug safety)

  • The ability to think creatively and strategically in order to enthuse not only the chemistry group, but also related groups with innovative ideas

  • The ability to coordinate and drive operational processes such as setting up a laboratory or establishing new initiatives, etc.

  • The ability to collaborate in a multidisciplinary and dynamic environment

  • The ability to communicate and present your work effectively in English, the shared language of our multicultural team

It is nice but not essential that you also have…

  • Experience in working across multiple target types across multiple disease indications

  • Experience in new chemical modalities (peptides, PROTACs, etc.)

  • Experience in driving successfully medicinal chemistry efforts ideally as project leader or in similar roles

About Dewpoint

Dewpoint Therapeutics is the first company founded to apply the emerging discipline of biomolecular condensates to drug discovery. Dewpoint believes that a vast range of conditions have pathways that are regulated by condensates or arise from the dysfunction of condensates — including cancer, neurodegeneration, and metabolic disease. Dewpoint scientists are working in Boston, MA, and Dresden and Frankfurt, Germany, to translate condensate biology into treatments for the toughest diseases.

Dewpoint Therapeutics is an equal opportunity employer committed to the principles of non-discrimination in the workplace. Candidates will not be discriminated against on the basis of age, race, creed, color, religion, sex, sexual orientation, national origin, disability, marital status, or any other basis prohibited by federal, state, or local law.

Dewpoint Therapeutics has an anti-hate policy in place, along with an active staff-led Diversity, Equity, and Inclusion Committee sponsored by the CEO.

Please, no solicitations by agencies.