Scientist / Sr. Scientist – Computational Chemistry (m/f/d)


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Dewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.

We are searching for an enthusiastic and highly motivated Scientist/Senior Scientist – Computational Chemistry to join in our interdisciplinary team focused on connecting biology, chemistry, and digital technology in the process of drug discovery and development.

In this position you’ll be part of an energizing and supportive startup culture engaged in continuous learning, and part of an exceptional international team. This role will be based at our site in Frankfurt, Germany. Dewpoint offers great benefits, competitive salary, and amazing perks.

In this role you will…

  • Drive the creation and utilization of tools to visualize project data, especially structure-activity relationships
  • Develop and implement computational approaches to drive HTS evaluation, hit-expansion, lead identification, and lead optimization programs

  • Develop and execute computational chemistry approaches to design molecules and predict their properties using state-of-the-art ligand-based and structure-based methodologies
  • Work in close collaboration with the data analysis team to apply AI/ML approaches to small molecules discovery

  • Gather, curate, and present literature data relevant to all projects, enabling better decision-making
  • Be part of project teams and collaborate closely with adjacent disciplines such as medicinal chemistry, biochemistry, structural biology, and DMPK

  • Become a valuable contributor to other initiatives as they arise in our fast paced, startup environment

To do that you will need…

  • A PhD in computational chemistry, cheminformatics, chemistry, life science informatics or a related field
  • 2+ years professional experience in computer-aided drug discovery

  • Experience in developing and implementing cutting-edge computational and informatics approaches in small molecule drug discovery programs

  • Ability to perform complex data integration, analysis, and visualization to drive project team decisions

  • Experience with cheminformatics analysis methods, AI/ML approaches required

  • Familiarity with computational chemistry packages (e.g. Schrödinger, MOE, etc.)  

  • Programming experience in at least one scripting language (e.g., Python), toolkits (e.g. RDKit), knowledge of pipelining tools, (e.g. KNIME) is preferred

  • A track record of scientific contributions evidenced by peer-reviewed publications and presentations at conferences

  • Ability to collaborate in a multidisciplinary and dynamic environment and experience in mentoring and leading scientific teams

  • Ability to communicate effectively in English, the shared language of our multicultural team


About Dewpoint

Dewpoint Therapeutics is the first company founded to apply the emerging discipline of biomolecular condensates to drug discovery. Dewpoint believes that a vast range of conditions have pathways that are regulated by condensates or arise from the dysfunction of condensates — including cancer, neurodegeneration, and metabolic disease. Dewpoint scientists are working in Boston, MA, and Dresden and Frankfurt, Germany, to translate condensate biology into treatments for the toughest diseases.

Dewpoint Therapeutics is an equal opportunity employer committed to the principles of non-discrimination in the workplace. Candidates will not be discriminated against on the basis of age, race, creed, color, religion, sex, sexual orientation, national origin, disability, marital status, or any other basis prohibited by federal, state, or local law.

Dewpoint Therapeutics has an anti-hate policy in place, along with an active staff-led Diversity, Equity, and Inclusion Committee sponsored by the CEO.

Please, no solicitations by agencies.