Principal Scientist – In Vitro Pharmacology (IVP)

Boston

Dewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging a transformative shift in the understanding of cellular biology to discover and advance breakthrough therapeutics for the toughest diseases.

We are searching for a Principal Scientist to lead from the bench, developing and executing robust disease-relevant cellular assays to support lead discovery and optimization.  You will have a strong scientific background in cellular biology, molecular biology, and biochemistry with experience in optimizing and validating robotic-based assays for high-throughput screening using a range of assay readouts, such as biochemical, indicator gene, gene expression (qPCR), and high content imaging. Experience in supporting hit-to-lead, and/or lead optimization programs and direct managerial experience is required. You will work closely with cross-functional teams and generate data that further our discovery efforts.

In this position you’ll be part of an energizing and supportive startup team culture, engaged in continuous learning, and part of an exceptional international team. This role is based at our site in Boston's Seaport district. Dewpoint offers competitive salary and benefits.

In this role you will…

  • Independently design, develop, and validate a variety of cell-based and biochemical assays to generate data in drug discovery projects, while incorporating the views of others
  • Develop, validate, and implement innovative and robust assays applicable to drive Structure Activity Relationship (SAR) and characterization of hits
  • Generate written SOPs, data reports, and routinely present findings to project team members
  • Work in partnership with colleagues in the High Throughput Screening and disease biology teams to ensure that assays and experiments are designed optimally, biologically relevant, aligned with goals, and implemented effectively
  • Independently interact with project teams as a core team member representing the in vitro pharmacology group to design detailed plans to enable lead identification, optimization, and characterization
  • Maintain an awareness of current developments in the literature and contribute to the continuous process to enhance functional capability and productivity
  • Supervise a team of 1 to 2 scientists
  • Provide mentorship and guidance as a team player while excelling as an independent, valuable contributor to other initiatives as they arise in our fast-paced environment

To do that you will need…

  • Ph.D. in chemical biology, biochemistry, molecular biology, cell biology, or a related field with >3 years’ industry experience or a B.S/M.S with > 8 years’ experience in bioassay/in vitro pharmacology
  • Hands-on experience in development and optimization of a wide range of cellular assays such as indicator gene (luciferase, GFP, SEAP etc), HTRF, AlphaLISA, MSD, qPCR, and high content imaging
  • Working knowledge of automation and liquid handling systems
  • Proficiency in utilizing software such as Spotfire, GraphPad, JMP, Microsoft office for data analysis & figure generation
  • Strong attention to detail and the ability to balance multiple objectives at the same time
  • Ability to collaborate in a multidisciplinary and dynamic environment and experience in mentoring and leading scientific other
  • Ability to communicate effectively in English, the shared language of our multicultural team

It is nice but not essential that you also have…

  • Experience in diverse molecular and cell biology techniques, including siRNA, CRISPR, sequencing, pull-down assays, western blots, fluorescence microscopy and flow cytometry
  • Proficiency in developing and implementing potency, selectivity, and mechanistic assays to drive lead discovery and optimization
  • Experience in programming and troubleshooting laboratory robotics such as LabCyte, Hamilton, Beckman, Agilent liquid handlers
  • Experience in supporting lead optimization programs and performing target validation
  • Skills in culturing and handling complex model systems such as iPSC-derived motor neurons, cardiomyocytes, and 3D organoids
  • Knowledge/experience in bioinformatics and programming for analysis of omics data or development of tools to improve data analysis
  • Experience with Design of Experiment (DoE) to accelerate assay optimization

About Dewpoint

Dewpoint Therapeutics is the first company founded to apply the emerging discipline of biomolecular condensates to drug discovery. Dewpoint believes that a vast range of conditions have pathways that are regulated by condensates or arise from the dysfunction of condensates — including cancer, neurodegeneration, and metabolic disease. Dewpoint scientists are working in Boston, MA, and Dresden and Frankfurt, Germany, to translate condensate biology into treatments for the toughest diseases.

Dewpoint Therapeutics is an equal opportunity employer committed to the principles of non-discrimination in the workplace. Candidates will not be discriminated against on the basis of age, race, creed, color, religion, sex, sexual orientation, national origin, disability, marital status, or any other basis prohibited by federal, state, or local law.

Dewpoint Therapeutics has an anti-hate policy in place, along with an active staff-led Diversity, Equity, and Inclusion Committee sponsored by the CEO.

Please, no solicitations by agencies.

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