We translate condensate biology into much-needed medicines.

  • Dewpoint is the leader in condensate drug discovery and development
  • Condensates are transforming our understanding of biology
  • Our condensate platform produces novel targets and life-changing medicines
Learn more or Meet the team
  • $147M Total venture financing
  • 51 Drugs brought to market by team
  • 3 Major pharma deals
  • $644M Potential pharma deal value to date

We have support from exceptional and .

Condensates’ transformative potential for drug discovery

Many vital cellular functions occur within biomolecular condensates

These droplets form dynamically throughout the cell via a process called phase separation. Their behavior is governed by weak multivalent interactions between proteins and nucleic acids.

Condensates compartmentalize and concentrate molecules, enabling key biochemical processes.

Aberrant condensates drive many diseases

When something goes awry with a condensate’s composition or behavior, we call it condensatopathy.

Condensatopathies can sequester proteins needed elsewhere in the cell, exclude proteins needed for critical processes, or have altered physical properties that lead to toxic gain of function.

C-mods treat the condensatopathies that drive disease

Condensate modulators (c-mods) are uniquely designed to hit condensate targets and reverse condensatopathies by:

  • preventing harmful protein sequestration
  • driving key components back into condensates
  • restoring healthy condensate properties and function

C-mods have the potential to alter the course of a disease.

Cause

Genetic and environmental factors

Condensatopathy

TDP43 sequestration

c-mod

Alters condensate composition to release TDP43

Downstream effects

Stathmin-2 mis-splicing, improper RNA trafficking, TDP43 proteinopathy

Disease

ALS

Our leading platform for discovering c-mods

Our comprehensive technology suite allows us to identify novel drugs across a wide spectrum of diseases.

Engine for genetically linked condensatopathy discovery

Machine-learning-based image analysis tools for visualizing condensates

Proprietary knowledge base of biomolecules in condensates

Compendium of all condensates in different cell types

Collection of engineered cell lines with trackable condensates

Suite of reconstituted physiologically relevant cell-free condensates

Condensate-directed medicinal chemistry

Methods for monitoring drug partitioning into condensates

Integrated machine learning platform automates, speeds, and enhances c-mod discovery

Our pipeline

Discovering and developing c-mods to address true unmet need

  • 11 Ongoing projects
  • 7 Disease areas

Cardiopulmonary

Multiple Partnering with

Virology

HIV Partnering with

Repeat Expansion Disorders

DM-1 Partnering with

Neurodegeneration

ALS

Oncology

Metastasis
(High-CIN)
Partnering with

Rare Disease

Wholly owned c-mods.

Building on condensate science, from concept to company

1903

1903Science

Condensates first observed

Peering through an early microscope, Santiago Ramón y Cajal saw membraneless structures now known to be condensates.

2009

2018

February, 2018Science

Potential of condensates identified

Phil Sharp identifies condensate biology as a once-in-a-generation opportunity to make transformative new medicines.

September, 2018Company

Dewpoint named

Founding team sketches out Dewpoint’s strategy. Suzanne Eaton, a brilliant scientist and partner to Tony Hyman, gives the company its name.

October, 2018Company

US operations begin

A new biology

The emerging science of biomolecular condensates could help answer some of biology’s biggest questions.

Learn more about condensates

Learn more about Dewpoint's history

Our founders and advisors explain how condensates drive cell function and solve biological mysteries.

Biomolecular condensates can fuse over time.

P granules segregate asymmetrically during embryogenesis.

Protein mutants cause aberrant phase transition.

A world-class team

Leading thinkers in cell biology, biophysics, drug discovery, and medicinal chemistry come together at Dewpoint.

Work with us

We are looking for passionate — and compassionate — scientists across a diverse set of scientific disciplines, including cell biology, high content cell imaging, biophysics, and proteomics.

See current job openings

Meet the team

What makes Dewpoint different from other places I've worked at? I'm now doing something transformative that's meaningful to me and I enjoy how inventive and creative it is here.

Sonia Joseph

It's this open minded community we have here and you're respected even if you're not a PhD. You can still contribute no matter what level you're at.

Theresa Simolka

The people and the science are phenomenal.

James Jung

I have a voice here and I'm respected here.

David Dachille

The fact that my colleagues value my input and my work is appreciated — that's the biggest thing.

Rob Nunes

Condensates.com

News, events, resources, and insights by and for the condensate community.

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