Condensates organize key molecules into specialized compartments that regulate essential cellular processes like transcription, signaling, and stress response. Many diseases are caused by abnormal condensate behavior that disrupts these functions. Because condensate properties differ between healthy and diseased states, they create an opportunity to selectively modulate disease-driving biology while leaving normal function in-tact.

Our platform is designed to identify and selectively target these pathological condensates using novel mechanisms that restore healthy function. Because condensates are enriched in disordered proteins that are hard to target with traditional approaches, this includes targets that were previously intractable with small molecules like beta-catenin, MYC, and TDP-43.